InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Tnfrsf11b

Summary

InnateDB Gene

IDBG-140472.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tnfrsf11b

Gene Name

tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)

Synonyms

OCIF; Opg; TR1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000063727

Encoded Proteins

IDBP-140474

tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164761:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:54250619-54278484

Strand

Reverse strand

Band

Transcripts

ENSMUST00000079772

ENSMUSP00000078705

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0007584	response to nutrient
GO:0010035	response to inorganic substance
GO:0030198	extracellular matrix organization
GO:0032026	response to magnesium ion
GO:0042489	negative regulation of odontogenesis of dentin-containing tooth
GO:0042493	response to drug
GO:0043627	response to estrogen
GO:0045779	negative regulation of bone resorption
GO:0046685	response to arsenic-containing substance

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000164761

View Gene Order

ENSBTAG00000007423

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04060

Cytokine-cytokine receptor interaction pathway

mmu04380

Osteoclast differentiation pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_21

RANKL pathway

REACTOME

KEGG

hsa04060

Cytokine-cytokine receptor interaction pathway

hsa04380

Osteoclast differentiation pathway

INOH

PID NCI

Cross-References

SwissProt

O08712

TrEMBL

Q3UK97

UniProt Splice Variant

Entrez Gene

18383

UniGene

Mm.15383 Mm.473332

RefSeq

NM_008764

OMIM

CCDS

CCDS27468

HPRD

IMGT

MGI ID

MGI:109587

MGI Symbol

Tnfrsf11b

EMBL

AB013898 AB013903 AK140244 AK146105 U94331

GenPept

AAB53708 BAA28269 BAA33388 BAE24295 BAE26905

RNA Seq Atlas

18383