Version 5.4
Homo sapiens Gene: TNFRSF11B
Summary
InnateDB Gene IDBG-33675.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNFRSF11B
Gene Name tumor necrosis factor receptor superfamily, member 11b
Synonyms OCIF; OPG; TR1
Species Homo sapiens
Ensembl Gene ENSG00000164761
Encoded Proteins
IDBP-33677
tumor necrosis factor receptor superfamily, member 11b
IDBP-475896
tumor necrosis factor receptor superfamily, member 11b
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:118923557-118952200
Strand Reverse strand
Band q24.12
Transcripts
ENST00000297350 ENSP00000297350
ENST00000521597
ENST00000517352 ENSP00000427924
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005125 cytokine activity
GO:0005515 protein binding
Biological Process
GO:0001501 skeletal system development
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0007584 response to nutrient
GO:0010035 response to inorganic substance
GO:0030198 extracellular matrix organization
GO:0032026 response to magnesium ion
GO:0042489 negative regulation of odontogenesis of dentin-containing tooth
GO:0042493 response to drug
GO:0043627 response to estrogen
GO:0045779 negative regulation of bone resorption
GO:0046685 response to arsenic-containing substance
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000063727
View Gene Order
ENSBTAG00000007423
Not yet available
Pathways
NETPATH
NetPath_21
RANKL pathway
REACTOME
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04380
Osteoclast differentiation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.81791
RefSeq NM_002546
HUGO
OMIM
CCDS CCDS6326
HPRD 04032
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca