Homo sapiens Gene: ATP5D
Summary
InnateDB Gene IDBG-14054.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATP5D
Gene Name ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000099624
Encoded Proteins
ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit
ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit
ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the delta subunit of the catalytic core. Alternatively spliced transcript variants encoding the same isoform have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:1241746-1244826
Strand Forward strand
Band p13.3
Transcripts
ENST00000215375 ENSP00000215375
ENST00000395633 ENSP00000378995
ENST00000591249 ENSP00000477964
ENST00000592624
ENST00000590265
ENST00000591660 ENSP00000464863
ENST00000588538
ENST00000589478
ENST00000614837
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005524 ATP binding
GO:0016887 ATPase activity
GO:0022857 transmembrane transporter activity
GO:0043531 ADP binding
GO:0046933 proton-transporting ATP synthase activity, rotational mechanism
GO:0046961 proton-transporting ATPase activity, rotational mechanism
Biological Process
GO:0006119 oxidative phosphorylation
GO:0006200 ATP catabolic process
GO:0006754 ATP biosynthetic process
GO:0015986 ATP synthesis coupled proton transport
GO:0022904 respiratory electron transport chain
GO:0042776 mitochondrial ATP synthesis coupled proton transport
GO:0044237 cellular metabolic process
GO:0044281 small molecule metabolic process
GO:0046688 response to copper ion
Cellular Component
GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005753 mitochondrial proton-transporting ATP synthase complex
GO:0005759 mitochondrial matrix
GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1)
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Formation of ATP by chemiosmotic coupling pathway
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway
The citric acid (TCA) cycle and respiratory electron transport pathway
Metabolism pathway
KEGG
Alzheimer's disease pathway
Oxidative phosphorylation pathway
Parkinson's disease pathway
Huntington's disease pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001001975 NM_001687
HUGO
OMIM
CCDS CCDS12058
HPRD 04397
IMGT
EMBL
GenPept
RNA Seq Atlas