Version 5.4
Homo sapiens Gene: ALKBH1
Summary
InnateDB Gene IDBG-14060.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ALKBH1
Gene Name alkB, alkylation repair homolog 1 (E. coli)
Synonyms ABH; ABH1; alkB; ALKBH; hABH
Species Homo sapiens
Ensembl Gene ENSG00000100601
Encoded Proteins
IDBP-14062
alkB, alkylation repair homolog 1 (E. coli)
IDBP-596911
alkB, alkylation repair homolog 1 (E. coli)
IDBP-587070
alkB, alkylation repair homolog 1 (E. coli)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a homolog to the E. coli alkB gene product. The E. coli alkB protein is part of the adaptive response mechanism of DNA alkylation damage repair. It is involved in damage reversal by oxidative demethylation of 1-methyladenine and 3-methylcytosine. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:77672404-77708020
Strand Reverse strand
Band q24.3
Transcripts
ENST00000216489 ENSP00000216489
ENST00000557057 ENSP00000451886
ENST00000555100 ENSP00000451386
ENST00000554097
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 2 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity
GO:0005515 protein binding
GO:0008198 ferrous iron binding
GO:0042056 chemoattractant activity
GO:0070579 methylcytosine dioxygenase activity
Biological Process
GO:0000737 DNA catabolic process, endonucleolytic
GO:0001701 in utero embryonic development
GO:0001764 neuron migration
GO:0001890 placenta development
GO:0006281 DNA repair
GO:0006307 DNA dealkylation involved in DNA repair
GO:0010468 regulation of gene expression
GO:0030154 cell differentiation
GO:0031175 neuron projection development
GO:0042245 RNA repair
GO:0043524 negative regulation of neuron apoptotic process
GO:0048589 developmental growth
GO:0050918 positive chemotaxis
GO:0055114 oxidation-reduction process
GO:0070989 oxidative demethylation
GO:0080111 DNA demethylation
Cellular Component
GO:0005719 nuclear euchromatin
GO:0005739 mitochondrion
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000079036
View Gene Order
ENSBTAG00000008133
Not yet available
Cross-References
SwissProt
TrEMBL G3V4M4 H0YJF3
UniProt Splice Variant
Entrez Gene 8846
UniGene Hs.601477 Hs.609889 Hs.94542
RefSeq NM_006020
HUGO HGNC:17911
OMIM 605345
CCDS CCDS32127
HPRD
IMGT
EMBL AC008044
GenPept
RNA Seq Atlas 8846

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca