InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ALKBH1

Summary

InnateDB Protein

IDBP-14062.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ALKBH1

Protein Name

alkB, alkylation repair homolog 1 (E. coli)

Synonyms

ABH; ABH1; alkB; ALKBH; hABH;

Species

Homo sapiens

Ensembl Protein

ENSP00000216489

InnateDB Gene

IDBG-14060 (ALKBH1)

Protein Structure

UniProt Annotation

Function

Dioxygenase that repairs alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation. Requires molecular oxygen, alpha-ketoglutarate and iron. May have a role in placental trophoblast lineage differentiation (By similarity). Has DNA lyase activity and introduces double-stranded breaks at abasic sites. Cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites. DNA lyase activity does not require alpha-ketoglutarate and iron. {ECO:0000250, ECO:0000269PubMed:18603530, ECO:0000269PubMed:19959401}.

Subcellular Localization

Mitochondrion {ECO:0000269PubMed:17979886, ECO:0000269PubMed:18603530}. Nucleus {ECO:0000250}. Note=Mainly localizes in euchromatin, largely excluded from heterochromatin and nucleoli. {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:17979886, ECO:0000269PubMed:18603530}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	2 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity
GO:0005515	protein binding
GO:0008198	ferrous iron binding
GO:0042056	chemoattractant activity
GO:0070579	methylcytosine dioxygenase activity

Biological Process

GO:0000737	DNA catabolic process, endonucleolytic
GO:0001701	in utero embryonic development
GO:0001764	neuron migration
GO:0001890	placenta development
GO:0006281	DNA repair
GO:0006307	DNA dealkylation involved in DNA repair
GO:0010468	regulation of gene expression
GO:0030154	cell differentiation
GO:0031175	neuron projection development
GO:0042245	RNA repair
GO:0043524	negative regulation of neuron apoptotic process
GO:0048589	developmental growth
GO:0050918	positive chemotaxis
GO:0055114	oxidation-reduction process
GO:0070989	oxidative demethylation
GO:0080111	DNA demethylation