InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Nxf1

Summary

InnateDB Gene

IDBG-140745.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nxf1

Gene Name

nuclear RNA export factor 1

Synonyms

0610006I08Rik; Mex67; Mvb1; Tap

Species

Mus musculus

Ensembl Gene

ENSMUSG00000010097

Encoded Proteins

IDBP-140747

nuclear RNA export factor 1 homolog (S. cerevisiae)

IDBP-789415

nuclear RNA export factor 1

IDBP-789416

nuclear RNA export factor 1

IDBP-789417

nuclear RNA export factor 1

IDBP-789418

nuclear RNA export factor 1

IDBP-789419

nuclear RNA export factor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000162231:
This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. It is the vertebrate homologue of the yeast protein Mex67p. The encoded protein overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:8757073-8772475

Strand

Forward strand

Band

Transcripts

ENSMUST00000010241	ENSMUSP00000010241
ENSMUST00000184970	ENSMUSP00000139124
ENSMUST00000183780
ENSMUST00000184756	ENSMUSP00000139050
ENSMUST00000183939	ENSMUSP00000139351
ENSMUST00000184663	ENSMUSP00000139090
ENSMUST00000185056
ENSMUST00000184387
ENSMUST00000184826	ENSMUSP00000139229
ENSMUST00000183898
ENSMUST00000184808

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 86 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	86 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003674	molecular_function
GO:0003723	RNA binding
GO:0003729	mRNA binding
GO:0005487	nucleocytoplasmic transporter activity
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006405	RNA export from nucleus
GO:0006406	mRNA export from nucleus
GO:0006810	transport
GO:0008150	biological_process
GO:0016973	poly(A)+ mRNA export from nucleus
GO:0051028	mRNA transport

Cellular Component

GO:0000346	transcription export complex
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005643	nuclear pore
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0016021	integral component of membrane
GO:0016607	nuclear speck
GO:0042405	nuclear inclusion body