InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nxf1

Summary

InnateDB Protein

IDBP-140747.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nxf1

Protein Name

nuclear RNA export factor 1 homolog (S. cerevisiae)

Synonyms

0610006I08Rik; Mex67; Mvb1; Tap;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000010241

InnateDB Gene

IDBG-140745 (Nxf1)

Protein Structure

UniProt Annotation

Function

Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex (By similaity). ALYREF/THOC4- or Alyref2/Refbp2-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export.

Subcellular Localization

Nucleus, nucleoplasm {ECO:0000250}. Nucleus speckle {ECO:0000255PROSITE-ProRule:PRU00611}. Cytoplasm {ECO:0000255PROSITE-ProRule:PRU00611}. Note=Localized predominantly in the nucleoplasm and at both the nucleoplasmic and cytoplasmic faces of the nuclear pore complex. Shuttles between the nucleus and the cytoplasm. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed ubiquitously.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 86 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	86 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003723	RNA binding
GO:0003729	mRNA binding
GO:0005487	nucleocytoplasmic transporter activity
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006405	RNA export from nucleus
GO:0006406	mRNA export from nucleus
GO:0006810	transport
GO:0016973	poly(A)+ mRNA export from nucleus
GO:0051028	mRNA transport

Cellular Component

GO:0000346	transcription export complex
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005643	nuclear pore
GO:0005737	cytoplasm
GO:0016607	nuclear speck
GO:0042405	nuclear inclusion body

Protein Structure and Domains

PDB ID

MGI:1858330

InterPro

IPR002075 Nuclear transport factor 2
IPR005637 TAP C-terminal (TAP-C) domain
IPR009060 UBA-like
IPR015245 Nuclear RNA export factor Tap, RNA-binding domain
IPR018222 Nuclear transport factor 2, eukaryote

PFAM

PF02136
PF03943
PF09162

PRINTS

PIRSF

SMART

SM00804

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q99JX7