InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: AQP9

Summary

InnateDB Gene

IDBG-14075.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AQP9

Gene Name

aquaporin 9

Synonyms

AQP-9; HsT17287; SSC1

Species

Homo sapiens

Ensembl Gene

ENSG00000103569

Encoded Proteins

IDBP-14077

aquaporin 9

IDBP-587141

aquaporin 9

IDBP-594467

aquaporin 9

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The aquaporins are a family of water-selective membrane channels. The protein encoded by this gene allows passage of a wide variety of noncharged solutes. It stimulates urea transport and osmotic water permeability; there are contradicting reports about its role in providing glycerol permeability. The encoded protein may also play a role in specialized leukocyte functions such as immunological response and bactericidal activity. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:58138169-58185911

Strand

Forward strand

Band

q21.3

Transcripts

ENST00000219919	ENSP00000219919
ENST00000558772	ENSP00000452673
ENST00000559443
ENST00000536493	ENSP00000441390

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	1 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005275	amine transmembrane transporter activity
GO:0005345	purine nucleobase transmembrane transporter activity
GO:0005350	pyrimidine nucleobase transmembrane transporter activity
GO:0005372	water transmembrane transporter activity
GO:0015166	polyol transmembrane transporter activity
GO:0015250	water channel activity
GO:0015254	glycerol channel activity
GO:0015288	porin activity
GO:0046943	carboxylic acid transmembrane transporter activity

Biological Process

GO:0006810	transport
GO:0006833	water transport
GO:0006863	purine nucleobase transport
GO:0006955	immune response
GO:0006970	response to osmotic stress
GO:0007588	excretion
GO:0008152	metabolic process
GO:0010033	response to organic substance
GO:0015722	canalicular bile acid transport
GO:0015791	polyol transport
GO:0015793	glycerol transport
GO:0015837	amine transport
GO:0015855	pyrimidine nucleobase transport
GO:0030104	water homeostasis
GO:0046689	response to mercury ion
GO:0046942	carboxylic acid transport
GO:0055085	transmembrane transport
GO:0071320	cellular response to cAMP
GO:0072531	pyrimidine-containing compound transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0043231	intracellular membrane-bounded organelle

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000032204

View Gene Order

ENSBTAG00000013452

Not yet available

Pathways

NETPATH

REACTOME

REACT_23809

Transport of glycerol from adipocytes to the liver by Aquaporins pathway

REACT_23826

Passive transport by Aquaporins pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_23887

Aquaporin-mediated transport pathway

KEGG

hsa04976

Bile secretion pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.104624

RefSeq

NM_020980

HUGO

OMIM

CCDS

CCDS10165

HPRD

04223

IMGT

EMBL

GenPept

RNA Seq Atlas