InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AQP9

Summary

InnateDB Protein

IDBP-14077.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AQP9

Protein Name

aquaporin 9

Synonyms

AQP-9; HsT17287; SSC1;

Species

Homo sapiens

Ensembl Protein

ENSP00000219919

InnateDB Gene

IDBG-14075 (AQP9)

Protein Structure

UniProt Annotation

Function

Forms a channel with a broad specificity. Mediates passage of a wide variety of non-charged solutes including carbamides, polyols, purines, and pyrimidines in a phloretin- and mercury-sensitive manner, whereas amino acids, cyclic sugars, Na(+), K(+), Cl(-), and deprotonated monocarboxylates are excluded. Also permeable to urea and glycerol. {ECO:0000269PubMed:10564231}.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Highly expressed in peripheral leukocytes. Also expressed in liver, lung, and spleen.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	1 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005275	amine transmembrane transporter activity
GO:0005345	purine nucleobase transmembrane transporter activity
GO:0005350	pyrimidine nucleobase transmembrane transporter activity
GO:0005372	water transmembrane transporter activity
GO:0015166	polyol transmembrane transporter activity
GO:0015250	water channel activity
GO:0015254	glycerol channel activity
GO:0015288	porin activity
GO:0046943	carboxylic acid transmembrane transporter activity

Biological Process

GO:0006810	transport
GO:0006833	water transport
GO:0006863	purine nucleobase transport
GO:0006955	immune response
GO:0006970	response to osmotic stress
GO:0007588	excretion
GO:0008152	metabolic process
GO:0010033	response to organic substance
GO:0015722	canalicular bile acid transport
GO:0015791	polyol transport
GO:0015793	glycerol transport
GO:0015837	amine transport
GO:0015855	pyrimidine nucleobase transport
GO:0030104	water homeostasis
GO:0046689	response to mercury ion
GO:0046942	carboxylic acid transport
GO:0055085	transmembrane transport
GO:0071320	cellular response to cAMP
GO:0072531	pyrimidine-containing compound transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0043231	intracellular membrane-bounded organelle