Version 5.4
Mus musculus Gene: Dgcr14
Summary
InnateDB Gene IDBG-140765.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dgcr14
Gene Name DiGeorge syndrome critical region gene 14
Synonyms AI462402; D16H22S1269E; Dgcr1; Dgsi; ES2; Es2el
Species Mus musculus
Ensembl Gene ENSMUSG00000003527
Encoded Proteins
IDBP-140767
DiGeorge syndrome critical region gene 14
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The human ortholog of this gene is located within the minimal DGS critical region (MDGCR) thought to contain the gene(s) responsible for a group of developmental disorders. These disorders include DiGeorge syndrome, velocardiofacial syndrome, conotruncal anomaly face syndrome, and some familial or sporadic conotruncal cardiac defects which have been associated with microdeletion of human chromosome band 22q11.2. The encoded protein localizes to the nucleus, and the orthologous protein in humans co-purifies with C complex spliceosomes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:17900711-17911348
Strand Reverse strand
Band A3
Transcripts
ENSMUST00000003621 ENSMUSP00000003621
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0006397 mRNA processing
GO:0007399 nervous system development
GO:0008380 RNA splicing
Cellular Component
GO:0005634 nucleus
GO:0071013 catalytic step 2 spliceosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000100056
View Gene Order
ENSBTAG00000018534
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.256480
RefSeq NM_001081633 NM_022408
OMIM
CCDS CCDS28013
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca