Version 5.4
Mus musculus Gene: Osbp2
Summary
InnateDB Gene IDBG-140794.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Osbp2
Gene Name oxysterol binding protein 2
Synonyms 1700095P05Rik; C630001G20Rik; Gm244; ORP-4; OSBPL1
Species Mus musculus
Ensembl Gene ENSMUSG00000020435
Encoded Proteins
IDBP-140796
oxysterol binding protein 2
IDBP-140798
oxysterol binding protein 2
IDBP-140802
oxysterol binding protein 2
IDBP-533867
oxysterol binding protein 2
IDBP-534446
oxysterol binding protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000184792:
Oxysterols are byproducts of cholesterol that can have cytotoxic effects on many cell types. The membrane-bound protein encoded by this gene contains a pleckstrin homology (PH) domain and an oxysterol-binding region. It binds oxysterols such as 7-ketocholesterol and may inhibit their cytotoxicity. Alternate transcriptional splice variants have been observed but have not been fully characterized. [provided by RefSeq, Jul 2008]
The protein encoded by this gene contains a pleckstrin homology (PH) domain and an oxysterol-binding region. It binds oxysterols such as 7-ketocholesterol and may inhibit their cytotoxicity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:3703731-3863903
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000070552 ENSMUSP00000068652
ENSMUST00000102950 ENSMUSP00000100015
ENSMUST00000101632 ENSMUSP00000099156
ENSMUST00000127371 ENSMUSP00000116361
ENSMUST00000155197 ENSMUSP00000116490
ENSMUST00000135250
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0015485 cholesterol binding
Biological Process
GO:0006869 lipid transport
GO:0008150 biological_process
Cellular Component
GO:0005575 cellular_component
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000184792
View Gene Order
ENSBTAG00000019146
Not yet available
Cross-References
SwissProt
TrEMBL Q5QNQ4 Q8K005 Q8K0C7
UniProt Splice Variant
Entrez Gene 74309
UniGene Mm.467949 Mm.474229 Mm.61022
RefSeq NM_152818 XM_006514849 XM_006514850 XM_006514851 XM_006514852 XM_006514853 XM_006514854 XM_006514855 XM_006514856 XM_006514858 XM_006514859 XM_006514860
OMIM
CCDS CCDS24367
HPRD
IMGT
MGI ID MGI:1921559
MGI Symbol Osbp2
EMBL AL691413 AL731853 BC031794 BC034567 BC058602
GenPept AAH31794 AAH34567 AAH58602
RNA Seq Atlas 74309

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca