Version 5.4
| Homo sapiens Gene: OSBP2 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-4309.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | OSBP2 | ||||||||||||||||||
| Gene Name | oxysterol binding protein 2 | ||||||||||||||||||
| Synonyms | HLM; ORP-4; ORP4; OSBPL1; OSBPL4 | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000184792 | ||||||||||||||||||
| Encoded Proteins |
oxysterol binding protein 2
oxysterol binding protein 2
oxysterol binding protein 2
oxysterol binding protein 2
oxysterol binding protein 2
oxysterol binding protein 2
oxysterol binding protein 2
oxysterol binding protein 2
oxysterol binding protein 2
oxysterol binding protein 2
oxysterol binding protein 2
oxysterol binding protein 2
oxysterol binding protein 2
oxysterol binding protein 2
oxysterol binding protein 2
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| Protein Structure | |||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
Oxysterols are byproducts of cholesterol that can have cytotoxic effects on many cell types. The membrane-bound protein encoded by this gene contains a pleckstrin homology (PH) domain and an oxysterol-binding region. It binds oxysterols such as 7-ketocholesterol and may inhibit their cytotoxicity. Alternate transcriptional splice variants have been observed but have not been fully characterized. [provided by RefSeq, Jul 2008] The protein encoded by this gene contains a pleckstrin homology (PH) domain and an oxysterol-binding region. It binds oxysterols such as 7-ketocholesterol and may inhibit their cytotoxicity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2013] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 22:30693782-30907824 | ||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||
| Band | q12.2 | ||||||||||||||||||
| Transcripts | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Cross-References | |||||||||||||||||||
| SwissProt | |||||||||||||||||||
| TrEMBL | C9J7J0 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 23762 | ||||||||||||||||||
| UniGene | Hs.517546 Hs.615076 Hs.734124 | ||||||||||||||||||
| RefSeq | NM_001282738 NM_001282739 NM_001282740 NM_001282741 NM_001282742 NM_030758 XM_006724204 XM_006724205 XM_006724206 XM_006724207 XM_006724208 XM_006724209 | ||||||||||||||||||
| HUGO | HGNC:8504 | ||||||||||||||||||
| OMIM | 606729 | ||||||||||||||||||
| CCDS | CCDS43002 CCDS63448 CCDS63449 CCDS63450 CCDS63451 | ||||||||||||||||||
| HPRD | 09471 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AC004542 AL022336 AL079299 | ||||||||||||||||||
| GenPept | |||||||||||||||||||
| RNA Seq Atlas | 102725085 23762 | ||||||||||||||||||