Version 5.4
Mus musculus Gene: Hesx1
Summary
InnateDB Gene IDBG-140811.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hesx1
Gene Name homeobox gene expressed in ES cells
Synonyms HES-1; Rpx
Species Mus musculus
Ensembl Gene ENSMUSG00000040726
Encoded Proteins
IDBP-140813
homeobox gene expressed in ES cells
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163666:
This gene encodes a conserved homeobox protein that is a transcriptional repressor in the developing forebrain and pituitary gland. Mutations in this gene are associated with septooptic dysplasia, HESX1-related growth hormone deficiency, and combined pituitary hormone deficiency. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:27000362-27002329
Strand Forward strand
Band A3
Transcripts
ENSMUST00000035433 ENSMUSP00000041999
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0008134 transcription factor binding
GO:0043565 sequence-specific DNA binding
GO:0047485 protein N-terminus binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007420 brain development
GO:0030916 otic vesicle formation
GO:0043584 nose development
GO:0045892 negative regulation of transcription, DNA-templated
GO:0048853 forebrain morphogenesis
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000163666
View Gene Order
ENSBTAG00000001439
Not yet available
Cross-References
SwissProt Q61658
TrEMBL
UniProt Splice Variant
Entrez Gene 15209
UniGene Mm.4802
RefSeq NM_010420 XM_006518570
OMIM
CCDS CCDS26884
HPRD
IMGT
MGI ID MGI:96071
MGI Symbol Hesx1
EMBL AC124603 AK082831 BC132051 BC132053 BC145262 U40720 X80040
GenPept AAA97869 AAI32052 AAI32054 AAI45263 BAC38643 CAA56344
RNA Seq Atlas 15209

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca