InnateDB Protein
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IDBP-140813.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Hesx1
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Protein Name
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homeobox gene expressed in ES cells
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Synonyms
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HES-1; Rpx;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000041999
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InnateDB Gene
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IDBG-140811 (Hesx1)
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Protein Structure
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Function |
Required for the normal development of the forebrain, eyes and other anterior structures such as the olfactory placodes and pituitary gland. Possible transcriptional repressor. Binds to the palindromic PIII sequence, 5'-AGCTTGAGTCTAATTGAATTAACTGTAC-3'. HESX1 and PROP1 bind as heterodimers on this palindromic site, and, in vitro, HESX1 can antagonize PROP1 activation. {ECO:0000269PubMed:9620767}.
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Subcellular Localization |
Nucleus {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
High levels found in the embryonic liver, lower level expression seen in the viscera, amnion and yolk sac.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
5
[view]
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Protein-Protein |
5
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
4 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:96071
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InterPro |
IPR001356
Homeobox domain
IPR009057
Homeodomain-like
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PFAM |
PF00046
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PRINTS |
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PIRSF |
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SMART |
SM00389
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TIGRFAMs |
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Modification |
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SwissProt |
Q61658
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
15209
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UniGene |
Mm.4802
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RefSeq |
NP_034550
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MGI ID |
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MGI Symbol |
Hesx1
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OMIM |
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CCDS |
CCDS26884
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HPRD |
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IMGT |
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EMBL |
AC124603
AK082831
BC132051
BC132053
BC145262
U40720
X80040
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GenPept |
AAA97869
AAI32052
AAI32054
AAI45263
BAC38643
CAA56344
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