InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Lnpep

Summary

InnateDB Gene

IDBG-140832.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lnpep

Gene Name

leucyl/cystinyl aminopeptidase

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000023845

Encoded Proteins

IDBP-140834

leucyl/cystinyl aminopeptidase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000113441:
This gene encodes a zinc-dependent aminopeptidase that cleaves vasopressin, oxytocin, lys-bradykinin, met-enkephalin, dynorphin A and other peptide hormones. The protein can be secreted in maternal serum, reside in intracellular vesicles with the insulin-responsive glucose transporter GLUT4, or form a type II integral membrane glycoprotein. The protein catalyzes the final step in the conversion of angiotensinogen to angiotensin IV (AT4) and is also a receptor for AT4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:17527723-17624489

Strand

Reverse strand

Band

A3.2

Transcripts

ENSMUST00000041047

ENSMUSP00000036998

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004177	aminopeptidase activity
GO:0005515	protein binding
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0006508	proteolysis
GO:0030163	protein catabolic process

Cellular Component

GO:0005622	intracellular
GO:0005765	lysosomal membrane
GO:0005886	plasma membrane
GO:0012505	endomembrane system
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030659	cytoplasmic vesicle membrane
GO:0048471	perinuclear region of cytoplasm