Version 5.4
| Mus musculus Gene: Dkk4 | |||||||
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| Summary | |||||||
| InnateDB Gene | IDBG-140894.6 | ||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
| Gene Symbol | Dkk4 | ||||||
| Gene Name | dickkopf homolog 4 (Xenopus laevis) | ||||||
| Synonyms | |||||||
| Species | Mus musculus | ||||||
| Ensembl Gene | ENSMUSG00000031535 | ||||||
| Encoded Proteins |
dickkopf homolog 4 (Xenopus laevis)
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||
| Entrez Gene | |||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000104371:
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. Activity of this protein is modulated by binding to the Wnt co-receptor and the co-factor kremen 2. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||
| Type | Protein coding | ||||||
| Genomic Location | Chromosome 8:22624043-22627536 | ||||||
| Strand | Forward strand | ||||||
| Band | A2 | ||||||
| Transcripts |
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| Interactions | |||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||
| NETPATH | |||||||
| REACTOME | |||||||
| KEGG |
Wnt signaling pathway pathway
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| INOH | |||||||
| PID NCI | |||||||
| Pathway Predictions based on Human Orthology Data | |||||||
| NETPATH | |||||||
| REACTOME |
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Signaling by WNT in cancer pathway
Signaling by Wnt pathway
Signal Transduction pathway
negative regulation of TCF-dependent signaling by WNT ligand antagonists pathway
TCF dependent signaling in response to WNT pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Disease pathway
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| KEGG |
Wnt signaling pathway pathway
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| INOH |
Wnt signaling pathway pathway
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| PID NCI |
Regulation of nuclear beta catenin signaling and target gene transcription
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| Cross-References | |||||||
| SwissProt | Q8VEJ3 | ||||||
| TrEMBL | |||||||
| UniProt Splice Variant | |||||||
| Entrez Gene | 234130 | ||||||
| UniGene | Mm.157322 | ||||||
| RefSeq | NM_145592 XM_006509098 XM_006509099 | ||||||
| OMIM | |||||||
| CCDS | CCDS22180 | ||||||
| HPRD | |||||||
| IMGT | |||||||
| MGI ID | MGI:2385299 | ||||||
| MGI Symbol | Dkk4 | ||||||
| EMBL | BC018400 | ||||||
| GenPept | AAH18400 | ||||||
| RNA Seq Atlas | 234130 | ||||||