Version 5.4
Homo sapiens Gene: DKK4
Summary
InnateDB Gene IDBG-20225.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DKK4
Gene Name dickkopf homolog 4 (Xenopus laevis)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000104371
Encoded Proteins
IDBP-20227
dickkopf homolog 4 (Xenopus laevis)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. Activity of this protein is modulated by binding to the Wnt co-receptor and the co-factor kremen 2. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:42374068-42377232
Strand Reverse strand
Band p11.21
Transcripts
ENST00000220812 ENSP00000220812
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0007275 multicellular organismal development
GO:0016055 Wnt signaling pathway
GO:0030178 negative regulation of Wnt signaling pathway
Cellular Component
GO:0005575 cellular_component
GO:0005576 extracellular region
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031535
View Gene Order
ENSBTAG00000000226
Not yet available
Pathways
NETPATH
REACTOME
REACT_228096
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_228331
Signaling by WNT in cancer pathway
REACT_11045
Signaling by Wnt pathway
REACT_111102
Signal Transduction pathway
REACT_200643
negative regulation of TCF-dependent signaling by WNT ligand antagonists pathway
REACT_200777
TCF dependent signaling in response to WNT pathway
REACT_228188
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_228279
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_116125
Disease pathway
KEGG
hsa04310
Wnt signaling pathway pathway
INOH
INOH website
Wnt signaling pathway pathway
PID NCI
betacatenin_nuc_pathway
Regulation of nuclear beta catenin signaling and target gene transcription
Cross-References
SwissProt Q9UBT3
TrEMBL
UniProt Splice Variant
Entrez Gene 27121
UniGene
RefSeq NM_014420
HUGO HGNC:2894
OMIM 605417
CCDS CCDS6130
HPRD
IMGT
EMBL AB017788 AB018005 AF177397 BC107046 BC107047
GenPept AAF02677 AAI07047 AAI07048 BAA33438 BAA33475
RNA Seq Atlas 27121

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca