Version 5.4
Mus musculus Gene: Dst
Summary
InnateDB Gene IDBG-140932.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dst
Gene Name dystonin
Synonyms 2310001O04Rik; A830042E19Rik; ah; athetoid; AW554249; BP230; Bpag; Bpag1; BPAG1-n; dt; Macf2; mKIAA0728; nmf203; nmf339
Species Mus musculus
Ensembl Gene ENSMUSG00000026131
Encoded Proteins
IDBP-140938
dystonin
IDBP-140940
dystonin
IDBP-250252
dystonin
IDBP-789980
dystonin
IDBP-789982
dystonin
IDBP-789983
dystonin
IDBP-789987
dystonin
IDBP-789989
dystonin
IDBP-789992
dystonin
IDBP-789996
dystonin
IDBP-789998
dystonin
IDBP-789999
dystonin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000151914:
This gene encodes a member of the plakin protein family of adhesion junction plaque proteins. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the full-length nature of some variants has not been defined. It has been reported that some isoforms are expressed in neural and muscle tissue, anchoring neural intermediate filaments to the actin cytoskeleton, and some isoforms are expressed in epithelial tissue, anchoring keratin-containing intermediate filaments to hemidesmosomes. Consistent with the expression, mice defective for this gene show skin blistering and neurodegeneration. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:33908225-34308661
Strand Forward strand
Band B
Transcripts
ENSMUST00000097786 ENSMUSP00000095393
ENSMUST00000097785 ENSMUSP00000095392
ENSMUST00000115104 ENSMUSP00000110756
ENSMUST00000182513 ENSMUSP00000138719
ENSMUST00000183034 ENSMUSP00000138308
ENSMUST00000187486 ENSMUSP00000140560
ENSMUST00000182697
ENSMUST00000182314
ENSMUST00000183331
ENSMUST00000182410
ENSMUST00000183006
ENSMUST00000190163
ENSMUST00000183302 ENSMUSP00000138376
ENSMUST00000185897 ENSMUSP00000139888
ENSMUST00000185269 ENSMUSP00000141127
ENSMUST00000182335
ENSMUST00000189952
ENSMUST00000182018 ENSMUSP00000138426
ENSMUST00000185736
ENSMUST00000183100 ENSMUSP00000138570
ENSMUST00000182507 ENSMUSP00000138591
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 49 interaction(s) predicted by orthology.
Predicted by orthology
Total 49 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005178 integrin binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0008022 protein C-terminus binding
GO:0042803 protein homodimerization activity
GO:0051010 microtubule plus-end binding
Biological Process
GO:0007050 cell cycle arrest
GO:0007409 axonogenesis
GO:0008090 retrograde axon cargo transport
GO:0009405 pathogenesis
GO:0009611 response to wounding
GO:0030011 maintenance of cell polarity
GO:0031110 regulation of microtubule polymerization or depolymerization
GO:0031122 cytoplasmic microtubule organization
GO:0031581 hemidesmosome assembly
GO:0048870 cell motility
Cellular Component
GO:0005634 nucleus
GO:0005856 cytoskeleton
GO:0015629 actin cytoskeleton
GO:0015630 microtubule cytoskeleton
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0030056 hemidesmosome
GO:0031252 cell leading edge
GO:0035371 microtubule plus-end
GO:0060053 neurofilament cytoskeleton
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000151914
View Gene Order
ENSBTAG00000021237
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_1
Alpha6Beta4Integrin pathway
REACTOME
REACT_20537
Type I hemidesmosome assembly pathway
REACT_111155
Cell-Cell communication pathway
REACT_20676
Cell junction organization pathway
KEGG
INOH
PID NCI
tap63pathway
Validated transcriptional targets of TAp63 isoforms
Cross-References
SwissProt
TrEMBL E9PXE5 E9Q9X1 E9QL23 Q80VL5 S4R1P5 S4R1U5 S4R288 S4R2N8
UniProt Splice Variant
Entrez Gene 13518
UniGene Mm.336625 Mm.486996
RefSeq NM_001276764 NM_010081 NM_133833 NM_134448 XM_006495662 XM_006495663 XM_006495666 XM_006495667 XM_006495669 XM_006495670 XM_006495671 XM_006495672 XM_006495673 XM_006495674 XM_006495675 XM_006495676 XM_006495677 XM_006495678 XM_006495679 XM_006495680 XM_006495682 XM_006495683 XM_006495684 XM_006495685 XM_006495686 XM_006495687 XM_006495688 XM_006495689 XM_006495690 XM_006495691
OMIM
CCDS CCDS35534 CCDS35535 CCDS69874 CCDS69875
HPRD
IMGT
MGI ID MGI:104627
MGI Symbol Dst
EMBL AC123072 AC124386 AC127433 BC048929
GenPept AAH48929
RNA Seq Atlas 13518

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca