InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Plat

Summary

InnateDB Gene

IDBG-141184.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Plat

Gene Name

plasminogen activator, tissue

Synonyms

AU020998; AW212668; D8Ertd2e; tPA

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031538

Encoded Proteins

IDBP-141186

plasminogen activator, tissue

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000104368:
This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:22757744-22782847

Strand

Forward strand

Band

Transcripts

ENSMUST00000033941

ENSMUSP00000033941

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005515	protein binding

Biological Process

GO:0001666	response to hypoxia
GO:0006508	proteolysis
GO:0014909	smooth muscle cell migration
GO:0031639	plasminogen activation
GO:0035249	synaptic transmission, glutamatergic
GO:0042060	wound healing
GO:0043434	response to peptide hormone
GO:0045861	negative regulation of proteolysis
GO:0048008	platelet-derived growth factor receptor signaling pathway
GO:0048167	regulation of synaptic plasticity
GO:0051384	response to glucocorticoid
GO:0051591	response to cAMP
GO:0060279	positive regulation of ovulation
GO:0071549	cellular response to dexamethasone stimulus

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0009986	cell surface
GO:0030141	secretory granule
GO:0045177	apical part of cell
GO:0045202	synapse
GO:0070062	extracellular vesicular exosome