InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Plat

Summary

InnateDB Protein

IDBP-141186.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Plat

Protein Name

plasminogen activator, tissue

Synonyms

AU020998; AW212668; D8Ertd2e; tPA;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033941

InnateDB Gene

IDBG-141184 (Plat)

Protein Structure

UniProt Annotation

Function

Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events.

Subcellular Localization

Secreted, extracellular space.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005515	protein binding

Biological Process

GO:0001666	response to hypoxia
GO:0006508	proteolysis
GO:0014909	smooth muscle cell migration
GO:0031639	plasminogen activation
GO:0035249	synaptic transmission, glutamatergic
GO:0042060	wound healing
GO:0043434	response to peptide hormone
GO:0045861	negative regulation of proteolysis
GO:0048008	platelet-derived growth factor receptor signaling pathway
GO:0048167	regulation of synaptic plasticity
GO:0051384	response to glucocorticoid
GO:0051591	response to cAMP
GO:0060279	positive regulation of ovulation
GO:0071549	cellular response to dexamethasone stimulus

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0009986	cell surface
GO:0030141	secretory granule
GO:0045177	apical part of cell
GO:0045202	synapse
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:97610

InterPro

IPR000001 Kringle
IPR000083 Fibronectin, type I
IPR000742 Epidermal growth factor-like domain
IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR009003 Trypsin-like cysteine/serine peptidase domain
IPR013806 Kringle-like fold

PFAM

PF00051
PF00039
PF00008
PF00089

PRINTS

PR00722

PIRSF

SMART

SM00130
SM00058
SM00181
SM00020

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt