Mus musculus Gene: Xiap | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-141324.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Xiap | ||||||||||||||||||||||
Gene Name | X-linked inhibitor of apoptosis | ||||||||||||||||||||||
Synonyms | 1110015C02Rik; Aipa; Api3; Birc4; IAP3; ILP-1; MIHA | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000025860 | ||||||||||||||||||||||
Encoded Proteins |
X-linked inhibitor of apoptosis
X-linked inhibitor of apoptosis
X-linked inhibitor of apoptosis
X-linked inhibitor of apoptosis
X-linked inhibitor of apoptosis
|
||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
InnateDB Annotation | |||||||||||||||||||||||
Summary |
Xiap facilitates ubiquitin-dependent signalling activated by pattern recognition receptors, such as TLR and NOD, to mediate the activation of NFKB transcription.
|
||||||||||||||||||||||
InnateDB Annotation from Orthologs | |||||||||||||||||||||||
Summary |
[Homo sapiens] XIAP regulates cytosol-specific innate immunity to Listeria infection.
[Homo sapiens] XIAP interacts with NOD1 and NOD2 and mediates NOD signalling via interaction with RIPK2.
[Homo sapiens] XIAP and its E3 ligase activity promote transforming growth factor-{beta}-mediated NF-kappaB activation during breast cancer progression.
[Homo sapiens] X-linked inhibitor of apoptosis protein (XIAP) in a complex with survivin, a physiological substrate for granzyme M (GzmM), act to inhibit caspase activation.
[Homo sapiens] XIAP facilitates ubiquitin-dependent signalling activated by pattern recognition receptors, such as TLR and NOD, to mediate the activation of NFKB transcription.
|
||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
The protein encoded by this gene is a member of the inhibitor of apoptosis (IAP) family of proteins. While first identified for its role in blocking apoptosis, this protein modulates many other signaling processes including nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) pathways and inflammatory responses. This protein blocks apoptosis by binding and inhibiting target caspases after they have been activated. Binding occurs to some, but not all, caspases. This protein has several conserved regions, including baculoviral IAP repeat (BIR) motifs and a RING finger E3 ligase domain. In humans, mutations in this gene are linked to immunodeficiency in X-linked lymphoproliferative syndrome type-2 (XLP-2). A pseudogene of this gene is found on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014] |
||||||||||||||||||||||
Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome X:42059679-42109656 | ||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||
Band | A4 | ||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 119 interaction(s) predicted by orthology.
|
||||||||||||||||||||||
Gene Ontology | |||||||||||||||||||||||
Molecular Function |
|
||||||||||||||||||||||
Biological Process |
|
||||||||||||||||||||||
Cellular Component |
|
||||||||||||||||||||||
Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
|
Gene ID
Gene Order
Not yet available
|
||||||||||||||||||||||
Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Apoptosis pathway
Disease pathway
SMAC-mediated dissociation of IAP:caspase complexes pathway
Signaling by Wnt pathway
Signaling by WNT in cancer pathway
SMAC-mediated apoptotic response pathway
deactivation of the beta-catenin transactivating complex pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
TCF dependent signaling in response to WNT pathway
SMAC binds to IAPs pathway
Signal Transduction pathway
Apoptotic factor-mediated response pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Intrinsic Pathway for Apoptosis pathway
|
||||||||||||||||||||||
KEGG |
Ubiquitin mediated proteolysis pathway
Small cell lung cancer pathway
Apoptosis pathway
Focal adhesion pathway
Pathways in cancer pathway
Toxoplasmosis pathway
|
||||||||||||||||||||||
INOH |
BMP2 signaling pathway
TGF-beta signaling pathway
|
||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH |
TNFalpha pathway
|
||||||||||||||||||||||
REACTOME |
SMAC-mediated dissociation of IAP:caspase complexes pathway
SMAC binds to IAPs pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Signaling by WNT in cancer pathway
SMAC-mediated apoptotic response pathway
Signaling by Wnt pathway
deactivation of the beta-catenin transactivating complex pathway
Apoptosis pathway
Signal Transduction pathway
Apoptotic factor-mediated response pathway
TCF dependent signaling in response to WNT pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
Intrinsic Pathway for Apoptosis pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Disease pathway
|
||||||||||||||||||||||
KEGG |
Apoptosis pathway
Ubiquitin mediated proteolysis pathway
Small cell lung cancer pathway
Focal adhesion pathway
Pathways in cancer pathway
Toxoplasmosis pathway
|
||||||||||||||||||||||
INOH |
TGF-beta signaling pathway
BMP2 signaling pathway
|
||||||||||||||||||||||
PID NCI |
Caspase Cascade in Apoptosis
BMP receptor signaling
TGF-beta receptor signaling
|
||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | A2BGY5 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 11798 | ||||||||||||||||||||||
UniGene | Mm.259879 Mm.413756 Mm.470261 Mm.470928 | ||||||||||||||||||||||
RefSeq | NM_009688 XM_006541422 XM_006541423 XM_006541424 XM_006541425 XM_006541426 XM_006541427 XM_006541428 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS30098 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
MGI ID | MGI:107572 | ||||||||||||||||||||||
MGI Symbol | Xiap | ||||||||||||||||||||||
EMBL | AL672089 BX530028 | ||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | 11798 | ||||||||||||||||||||||