InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Car9

Summary

InnateDB Gene

IDBG-141349.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Car9

Gene Name

carbonic anhydrase 9

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028463

Encoded Proteins

IDBP-141351

carbonic anhydrase 9

IDBP-535281

carbonic anhydrase 9

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000107159:
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and the only tumor-associated carbonic anhydrase isoenzyme known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12. [provided by RefSeq, Jul 2008]
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and is one of only two tumor-associated carbonic anhydrase isoenzymes known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12. [provided by RefSeq, Jun 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:43506966-43513729

Strand

Forward strand

Band

Transcripts

ENSMUST00000030183	ENSMUSP00000030183
ENSMUST00000124114
ENSMUST00000138073	ENSMUSP00000114493
ENSMUST00000128232
ENSMUST00000126750
ENSMUST00000129996
ENSMUST00000154251

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004089	carbonate dehydratase activity
GO:0008270	zinc ion binding

Biological Process

GO:0001666	response to hypoxia
GO:0002009	morphogenesis of an epithelium
GO:0006730	one-carbon metabolic process
GO:0033574	response to testosterone
GO:0042493	response to drug
GO:0046903	secretion