Version 5.4
Mus musculus Gene: Stag2
Summary
InnateDB Gene IDBG-141393.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Stag2
Gene Name stromal antigen 2
Synonyms 9230105L23Rik; B230112I07Rik; SA-2; SAP2
Species Mus musculus
Ensembl Gene ENSMUSG00000025862
Encoded Proteins
IDBP-141395
stromal antigen 2
IDBP-250405
stromal antigen 2
IDBP-250407
stromal antigen 2
IDBP-538916
stromal antigen 2
IDBP-536774
stromal antigen 2
IDBP-538136
stromal antigen 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101972:
The protein encoded by this gene is a subunit of the cohesin complex, which regulates the separation of sister chromatids during cell division. Targeted inactivation of this gene results in chromatid cohesion defects and aneuploidy, suggesting that genetic disruption of cohesin is a cause of aneuploidy in human cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome X:42149317-42277185
Strand Forward strand
Band A4
Transcripts
ENSMUST00000069619 ENSMUSP00000063250
ENSMUST00000115073 ENSMUSP00000110725
ENSMUST00000115072 ENSMUSP00000110724
ENSMUST00000136323
ENSMUST00000127618 ENSMUSP00000119635
ENSMUST00000141414
ENSMUST00000123245 ENSMUSP00000118567
ENSMUST00000128799 ENSMUSP00000120592
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.
Experimentally validated
Total 22 [view]
Protein-Protein 22 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 34 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0007062 sister chromatid cohesion
GO:0007067 mitotic nuclear division
GO:0007126 meiotic nuclear division
GO:0019827 stem cell maintenance
GO:0032876 negative regulation of DNA endoreduplication
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005886 plasma membrane
GO:0015629 actin cytoskeleton
GO:0016020 membrane
GO:0045111 intermediate filament cytoskeleton
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000101972
View Gene Order
ENSBTAG00000009121
Not yet available
Pathways
NETPATH
REACTOME
REACT_75800
Meiotic Synapsis pathway
REACT_200794
Mus musculus biological processes pathway
REACT_249770
Cell Cycle, Mitotic pathway
REACT_207679
Separation of Sister Chromatids pathway
REACT_198961
Resolution of Sister Chromatid Cohesion pathway
REACT_198626
Meiotic synapsis pathway
REACT_188804
Cell Cycle pathway
REACT_241408
M Phase pathway
REACT_250427
Mitotic Telophase/Cytokinesis pathway
REACT_199403
Mitotic Metaphase and Anaphase pathway
REACT_256756
Mitotic Prometaphase pathway
REACT_196634
Cohesin Loading onto Chromatin pathway
REACT_196614
Establishment of Sister Chromatid Cohesion pathway
REACT_198624
Meiosis pathway
REACT_202512
Mitotic Anaphase pathway
REACT_253623
S Phase pathway
KEGG
mmu04110
Cell cycle pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_75792
Meiotic synapsis pathway
REACT_150425
Resolution of Sister Chromatid Cohesion pathway
REACT_682
Mitotic Prometaphase pathway
REACT_150471
Separation of Sister Chromatids pathway
REACT_150421
Cohesin Loading onto Chromatin pathway
REACT_1932
Mitotic Telophase/Cytokinesis pathway
REACT_150266
Establishment of Sister Chromatid Cohesion pathway
REACT_899
S Phase pathway
REACT_115566
Cell Cycle pathway
REACT_910
M Phase pathway
REACT_1275
Mitotic Anaphase pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_111183
Meiosis pathway
REACT_150314
Mitotic Metaphase and Anaphase pathway
KEGG
hsa04110
Cell cycle pathway
INOH
PID NCI
plk1_pathway
PLK1 signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.290422 Mm.402019 Mm.437888 Mm.470372
RefSeq NM_001077712 NM_001290713 NM_021465 XM_006541453
OMIM
CCDS CCDS40952 CCDS72371
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca