InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: STAG2

Summary

InnateDB Gene

IDBG-629999.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STAG2

Gene Name

cohesin subunit SA-2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000009121

Encoded Proteins

IDBP-681636

stromal antigen 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101972:
The protein encoded by this gene is a subunit of the cohesin complex, which regulates the separation of sister chromatids during cell division. Targeted inactivation of this gene results in chromatid cohesion defects and aneuploidy, suggesting that genetic disruption of cohesin is a cause of aneuploidy in human cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:7938893-8018893

Strand

Forward strand

Band

Transcripts

ENSBTAT00000012029

ENSBTAP00000012029

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 37 interaction(s) predicted by orthology.

Predicted by orthology
Total	37 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0005488	binding
GO:0005515	protein binding

Biological Process

GO:0007062	sister chromatid cohesion
GO:0019827	stem cell maintenance
GO:0032876	negative regulation of DNA endoreduplication

Cellular Component

GO:0000785	chromatin
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005886	plasma membrane
GO:0015629	actin cytoskeleton
GO:0016020	membrane
GO:0045111	intermediate filament cytoskeleton