Version 5.4
Mus musculus Gene: Mfsd8
Summary
InnateDB Gene IDBG-141543.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mfsd8
Gene Name major facilitator superfamily domain containing 8
Synonyms 2810423E13Rik; AI836898; AV142426; Cln7
Species Mus musculus
Ensembl Gene ENSMUSG00000025759
Encoded Proteins
IDBP-141545
major facilitator superfamily domain containing 8
IDBP-540693
major facilitator superfamily domain containing 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164073:
This gene encodes a ubiquitous integral membrane protein that contains a transporter domain and a major facilitator superfamily (MFS) domain. Other members of the major facilitator superfamily transport small solutes through chemiosmotic ion gradients. The substrate transported by this protein is unknown. The protein likely localizes to lysosomal membranes. Mutations in this gene are correlated with a variant form of late infantile-onset neuronal ceroid lipofuscinoses (vLINCL). [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:40818070-40846885
Strand Reverse strand
Band B
Transcripts
ENSMUST00000026859 ENSMUSP00000026859
ENSMUST00000137533 ENSMUSP00000121436
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0022857 transmembrane transporter activity
Biological Process
GO:0008150 biological_process
GO:0055085 transmembrane transport
Cellular Component
GO:0005634 nucleus
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0016021 integral component of membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000164073
View Gene Order
ENSBTAG00000044058
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04142
Lysosome pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04142
Lysosome pathway
INOH
PID NCI
Cross-References
SwissProt Q8BH31
TrEMBL
UniProt Splice Variant
Entrez Gene 72175
UniGene
RefSeq NM_028140 XM_006500788
OMIM
CCDS CCDS17329
HPRD
IMGT
MGI ID MGI:1919425
MGI Symbol Mfsd8
EMBL AK013144 AK032080 AK077957 BC010483 BC113183 BC113790
GenPept AAH10483 AAI13184 AAI13791 BAB28676 BAC27687 BAC37083
RNA Seq Atlas 72175

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca