InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mfsd8

Summary

InnateDB Protein

IDBP-141545.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mfsd8

Protein Name

major facilitator superfamily domain containing 8

Synonyms

2810423E13Rik; AI836898; AV142426; Cln7;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026859

InnateDB Gene

IDBG-141543 (Mfsd8)

Protein Structure

UniProt Annotation

Function

May be a carrier that transport small solutes by using chemiosmotic ion gradients. {ECO:0000305}.

Subcellular Localization

Lysosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Sorting to lysosomes involves tyrosine- and/or dileucine-based motifs. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0022857	transmembrane transporter activity

Biological Process

GO:0008150	biological_process
GO:0055085	transmembrane transport

Cellular Component

GO:0005634	nucleus
GO:0005764	lysosome
GO:0005765	lysosomal membrane
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

MGI:1919425

InterPro

IPR005828 General substrate transporter
IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR020846 Major facilitator superfamily domain

PFAM

PF00083
PF07690

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8BH31

PhosphoSite