InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Clcn4-2

Summary

InnateDB Gene

IDBG-141586.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Clcn4-2

Gene Name

chloride channel 4-2

Synonyms

Clc4-2; Clcn4

Species

Mus musculus

Ensembl Gene

ENSMUSG00000000605

Encoded Proteins

IDBP-141588

chloride channel 4-2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000073464:
The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 4 has an evolutionary conserved CpG island and is conserved in both mouse and hamster. This gene is mapped in close proximity to APXL (Apical protein Xenopus laevis-like) and OA1 (Ocular albinism type I), which are both located on the human X chromosome at band p22.3. The physiological role of chloride channel 4 remains unknown but may contribute to the pathogenesis of neuronal disorders. Alternate splicing results in two transcript variants that encode different proteins. [provided by RefSeq, Mar 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:7282316-7299511

Strand

Reverse strand

Band

Transcripts

ENSMUST00000000619

ENSMUSP00000000619

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005247	voltage-gated chloride channel activity
GO:0005254	chloride channel activity
GO:0005524	ATP binding
GO:0015297	antiporter activity
GO:0030554	adenyl nucleotide binding

Biological Process

GO:0006821	chloride transport
GO:0044070	regulation of anion transport
GO:0055085	transmembrane transport
GO:1902476	chloride transmembrane transport

Cellular Component

GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031901	early endosome membrane
GO:0031902	late endosome membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000073464

View Gene Order

ENSBTAG00000011121

Not yet available

Pathways

NETPATH

REACTOME

REACT_196640

Stimuli-sensing channels pathway

REACT_262350

Ion channel transport pathway

REACT_253400

Transmembrane transport of small molecules pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_160189

Stimuli-sensing channels pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_25300

Ion channel transport pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

Q61418

TrEMBL

Q3LRV6 Q8BQG0

UniProt Splice Variant

Entrez Gene

12727

UniGene

Mm.297883 Mm.398584

RefSeq

NM_011334 XM_006539501 XM_006539502 XM_006539503

OMIM

CCDS

CCDS20786

HPRD

IMGT

MGI ID

MGI:104571

MGI Symbol

Clcn4-2

EMBL

AK050833 BC110668 CH466983 DQ186662 Z49916

GenPept

AAI10669 ABA28317 BAC34428 CAA90150 EDL01090

RNA Seq Atlas

12727