Version 5.4
Mus musculus Protein: Clcn4-2
Summary
InnateDB Protein IDBP-141588.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Clcn4-2
Protein Name chloride channel 4-2
Synonyms Clc4-2; Clcn4;
Species Mus musculus
Ensembl Protein ENSMUSP00000000619
InnateDB Gene IDBG-141586 (Clcn4-2)
Protein Structure
UniProt Annotation
Function Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons (By similarity). {ECO:0000250}.
Subcellular Localization Early endosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Late endosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005247 voltage-gated chloride channel activity
GO:0005254 chloride channel activity
GO:0005524 ATP binding
GO:0015297 antiporter activity
GO:0030554 adenyl nucleotide binding
Biological Process
GO:0006821 chloride transport
GO:0044070 regulation of anion transport
GO:0055085 transmembrane transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031901 early endosome membrane
GO:0031902 late endosome membrane
Protein Structure and Domains
PDB ID MGI:104571
InterPro IPR000644 CBS domain
IPR001807 Chloride channel, voltage gated
IPR002246 Chloride channel ClC-4
IPR014743 Chloride channel, core
PFAM PF00571
PF00654
PRINTS PR00762
PR01115
PIRSF
SMART SM00116
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q61418
PhosphoSite PhosphoSite-Q61418
TrEMBL Q8BQG0
UniProt Splice Variant
Entrez Gene 12727
UniGene Mm.398584
RefSeq NP_035464
MGI ID
MGI Symbol Clcn4-2
OMIM
CCDS CCDS20786
HPRD
IMGT
EMBL AK050833 BC110668 CH466983 DQ186662 Z49916
GenPept AAI10669 ABA28317 BAC34428 CAA90150 EDL01090

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca