InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Sstr1

Summary

InnateDB Gene

IDBG-141648.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sstr1

Gene Name

somatostatin receptor 1

Synonyms

Smstr-1; Smstr1; SRIF-2; SS-1-R; SS1-R; SS1R; sst1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000035431

Encoded Proteins

IDBP-141650

somatostatin receptor 1

IDBP-259785

somatostatin receptor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000139874:
Somatostatins are peptide hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as well as inhibiting the release of many hormones and other secretory proteins. Somatostatin has two active forms of 14 and 28 amino acids. The biological effects of somatostatins are mediated by a family of G-protein coupled somatostatin receptors that are expressed in a tissue-specific manner. The protein encoded by this gene is a member of the superfamily of somatostatin receptors having seven transmembrane segments. Somatostatin receptors form homodimers and heterodimers with other members of the superfamily as well as with other G-protein coupled receptors and receptor tyrosine kinases. This somatostatin receptor has greater affinity for somatostatin-14 than -28. [provided by RefSeq, Jul 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:58211772-58214444

Strand

Forward strand

Band

Transcripts

ENSMUST00000044299	ENSMUSP00000037045
ENSMUST00000110671	ENSMUSP00000106299

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004994	somatostatin receptor activity
GO:0005515	protein binding

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007215	glutamate receptor signaling pathway
GO:0007218	neuropeptide signaling pathway
GO:0007283	spermatogenesis
GO:0021549	cerebellum development
GO:0030900	forebrain development
GO:0038170	somatostatin signaling pathway
GO:0042594	response to starvation
GO:0071392	cellular response to estradiol stimulus