InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SSTR1

Summary

InnateDB Gene

IDBG-5172.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SSTR1

Gene Name

somatostatin receptor 1

Synonyms

SRIF-2; SS-1-R; SS1-R; SS1R

Species

Homo sapiens

Ensembl Gene

ENSG00000139874

Encoded Proteins

IDBP-5174

somatostatin receptor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Somatostatins are peptide hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as well as inhibiting the release of many hormones and other secretory proteins. Somatostatin has two active forms of 14 and 28 amino acids. The biological effects of somatostatins are mediated by a family of G-protein coupled somatostatin receptors that are expressed in a tissue-specific manner. The protein encoded by this gene is a member of the superfamily of somatostatin receptors having seven transmembrane segments. Somatostatin receptors form homodimers and heterodimers with other members of the superfamily as well as with other G-protein coupled receptors and receptor tyrosine kinases. This somatostatin receptor has greater affinity for somatostatin-14 than -28. [provided by RefSeq, Jul 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:38207999-38213067

Strand

Forward strand

Band

q21.1

Transcripts

ENST00000267377

ENSP00000267377

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	4 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004994	somatostatin receptor activity
GO:0005515	protein binding

Biological Process

GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007215	glutamate receptor signaling pathway
GO:0007218	neuropeptide signaling pathway
GO:0007267	cell-cell signaling
GO:0007283	spermatogenesis
GO:0007584	response to nutrient
GO:0007586	digestion
GO:0008285	negative regulation of cell proliferation
GO:0021549	cerebellum development
GO:0030900	forebrain development
GO:0042594	response to starvation
GO:0071392	cellular response to estradiol stimulus

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000035431

View Gene Order

ENSBTAG00000006582

Not yet available

Pathways

NETPATH

REACTOME

REACT_19231

G alpha (i) signalling events pathway

REACT_14819

Peptide ligand-binding receptors pathway

REACT_14828

Class A/1 (Rhodopsin-like receptors) pathway

REACT_14797

Signaling by GPCR pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

REACT_21340

GPCR ligand binding pathway

KEGG

hsa04080

Neuroactive ligand-receptor interaction pathway

INOH

PID NCI

Cross-References

SwissProt

P30872

TrEMBL

UniProt Splice Variant

Entrez Gene

6751

UniGene

Hs.248160

RefSeq

NM_001049

HUGO

HGNC:11330

OMIM

182451

CCDS

CCDS9666

HPRD

IMGT

EMBL

AY322536 BC035618 M81829

GenPept

AAA58247 AAH35618 AAP84349

RNA Seq Atlas

6751