Version 5.4
Mus musculus Gene: Ido2
Summary
InnateDB Gene IDBG-142369.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ido2
Gene Name indoleamine 2,3-dioxygenase 2
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000031549
Encoded Proteins
IDBP-401545
indoleamine 2,3-dioxygenase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000188676:
Along with the enzymes encoded by the INDO (MIM 147435) and TDO2 (MIM 191070) genes, the enzyme encoded by the INDOL1 gene metabolizes tryptophan in the kynurenine pathway (Ball et al., 2007 [PubMed 17499941]).[supplied by OMIM, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:24531894-24576333
Strand Reverse strand
Band A2
Transcripts
ENSMUST00000121992 ENSMUSP00000113979
ENSMUST00000140417
ENSMUST00000138335
ENSMUST00000138155
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004833 tryptophan 2,3-dioxygenase activity
GO:0020037 heme binding
GO:0033754 indoleamine 2,3-dioxygenase activity
GO:0046872 metal ion binding
Biological Process
GO:0019441 tryptophan catabolic process to kynurenine
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000188676
View Gene Order
ENSBTAG00000005725
Not yet available
Pathways
NETPATH
REACTOME
REACT_188937
Metabolism pathway
REACT_232845
Metabolism of amino acids and derivatives pathway
REACT_240936
Tryptophan catabolism pathway
KEGG
mmu00380
Tryptophan metabolism pathway
mmu05143
African trypanosomiasis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_916
Tryptophan catabolism pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_111217
Metabolism pathway
KEGG
hsa00380
Tryptophan metabolism pathway
hsa05143
African trypanosomiasis pathway
INOH
PID NCI
Cross-References
SwissProt Q8R0V5
TrEMBL A4UHF3 B1AC39
UniProt Splice Variant
Entrez Gene 209176
UniGene Mm.219580 Mm.398187
RefSeq NM_145949 XM_006509047
OMIM
CCDS CCDS40298
HPRD
IMGT
MGI ID MGI:2142489
MGI Symbol Ido2
EMBL AC114602 BC026393 CH466580 EF137182 EU440733
GenPept AAH26393 ABO33433 ACA25598 EDL32857
RNA Seq Atlas 209176

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca