Version 5.4
Homo sapiens Gene: IDO2
Summary
InnateDB Gene IDBG-18785.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IDO2
Gene Name indoleamine 2,3-dioxygenase 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000188676
Encoded Proteins
IDBP-483798
indoleamine 2,3-dioxygenase 2
IDBP-592980
indoleamine 2,3-dioxygenase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Along with the enzymes encoded by the INDO (MIM 147435) and TDO2 (MIM 191070) genes, the enzyme encoded by the INDOL1 gene metabolizes tryptophan in the kynurenine pathway (Ball et al., 2007 [PubMed 17499941]).[supplied by OMIM, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:39934614-40016391
Strand Forward strand
Band p11.21
Transcripts
ENST00000343295
ENST00000389060 ENSP00000426447
ENST00000418094
ENST00000502986 ENSP00000443432
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004833 tryptophan 2,3-dioxygenase activity
GO:0020037 heme binding
GO:0033754 indoleamine 2,3-dioxygenase activity
GO:0046872 metal ion binding
Biological Process
GO:0006569 tryptophan catabolic process
GO:0019441 tryptophan catabolic process to kynurenine
GO:0034641 cellular nitrogen compound metabolic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031549
View Gene Order
ENSBTAG00000005725
Not yet available
Pathways
NETPATH
REACTOME
REACT_916
Tryptophan catabolism pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_111217
Metabolism pathway
KEGG
hsa00380
Tryptophan metabolism pathway
hsa05143
African trypanosomiasis pathway
INOH
PID NCI
Cross-References
SwissProt Q6ZQW0
TrEMBL
UniProt Splice Variant
Entrez Gene 169355
UniGene Hs.676257
RefSeq NM_194294
HUGO HGNC:27269
OMIM 612129
CCDS
HPRD 14113
IMGT
EMBL AC007991 AC087518 AK128691 BC113496 BC113498 EF052681
GenPept AAI13497 AAI13499 ABM69260 BAC87573
RNA Seq Atlas 169355

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca