Version 5.4
Mus musculus Gene: Apln
Summary
InnateDB Gene IDBG-142667.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Apln
Gene Name apelin
Synonyms 6030430G11Rik; Apel
Species Mus musculus
Ensembl Gene ENSMUSG00000037010
Encoded Proteins
IDBP-142669
apelin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome X:48025146-48034853
Strand Reverse strand
Band A5
Transcripts
ENSMUST00000039026 ENSMUSP00000046012
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005179 hormone activity
GO:0031704 apelin receptor binding
Biological Process
GO:0002026 regulation of the force of heart contraction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007631 feeding behavior
GO:0008284 positive regulation of cell proliferation
GO:0031652 positive regulation of heat generation
GO:0042327 positive regulation of phosphorylation
GO:0042756 drinking behavior
GO:0043576 regulation of respiratory gaseous exchange
GO:0045776 negative regulation of blood pressure
GO:0045906 negative regulation of vasoconstriction
GO:0045909 positive regulation of vasodilation
GO:0050878 regulation of body fluid levels
GO:0051461 positive regulation of corticotropin secretion
GO:0051466 positive regulation of corticotropin-releasing hormone secretion
Cellular Component
GO:0005615 extracellular space
GO:0048471 perinuclear region of cytoplasm
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_223625
GPCR downstream signaling pathway
REACT_254215
Signaling by GPCR pathway
REACT_261161
Class A/1 (Rhodopsin-like receptors) pathway
REACT_231468
GPCR ligand binding pathway
REACT_235286
Peptide ligand-binding receptors pathway
REACT_250376
G alpha (i) signalling events pathway
REACT_188257
Signal Transduction pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9R0R4
TrEMBL Q544B5
UniProt Splice Variant
Entrez Gene 30878
UniGene Mm.29262
RefSeq NM_013912
OMIM
CCDS CCDS40958
HPRD
IMGT
MGI ID MGI:1353624
MGI Symbol Apln
EMBL AB023494 AJ290423 AK042076 BC020015 DQ832282
GenPept AAH20015 ABI30216 BAA84976 BAC31156 CAC83678
RNA Seq Atlas 30878

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca