InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Apln

Summary

InnateDB Protein

IDBP-142669.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Apln

Protein Name

apelin

Synonyms

6030430G11Rik; Apel;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000046012

InnateDB Gene

IDBG-142667 (Apln)

Protein Structure

UniProt Annotation

Function

Endogenous ligand for APJ. Has an inhibitory effect on cytokine production in response to T-cell receptor/CD3 cross- linking. The oral intake of apelin in the colostrum and the milk might therefore modulate immune responses in neonates. May also have a role in the central control of body fluid homeostasis by influencing AVP release and drinking behavior.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005179	hormone activity
GO:0031704	apelin receptor binding

Biological Process

GO:0002026	regulation of the force of heart contraction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007631	feeding behavior
GO:0008284	positive regulation of cell proliferation
GO:0031652	positive regulation of heat generation
GO:0042327	positive regulation of phosphorylation
GO:0042756	drinking behavior
GO:0043576	regulation of respiratory gaseous exchange
GO:0045776	negative regulation of blood pressure
GO:0045906	negative regulation of vasoconstriction
GO:0045909	positive regulation of vasodilation
GO:0050878	regulation of body fluid levels
GO:0051461	positive regulation of corticotropin secretion
GO:0051466	positive regulation of corticotropin-releasing hormone secretion