Mus musculus Gene: Fth1 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-142805.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Fth1 | ||||||||||||||||||||||
Gene Name | ferritin heavy chain 1 | ||||||||||||||||||||||
Synonyms | FHC; Fth; HFt; MFH | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000024661 | ||||||||||||||||||||||
Encoded Proteins |
ferritin heavy chain 1
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000167996:
This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 19:9982703-9985092 | ||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||
Band | A | ||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Membrane Trafficking pathway
Binding and Uptake of Ligands by Scavenger Receptors pathway
Golgi Associated Vesicle Biogenesis pathway
Scavenging by Class A Receptors pathway
Iron uptake and transport pathway
trans-Golgi Network Vesicle Budding pathway
Transmembrane transport of small molecules pathway
Clathrin derived vesicle budding pathway
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KEGG | |||||||||||||||||||||||
INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Iron uptake and transport pathway
Golgi Associated Vesicle Biogenesis pathway
Clathrin derived vesicle budding pathway
Transmembrane transport of small molecules pathway
trans-Golgi Network Vesicle Budding pathway
Binding and Uptake of Ligands by Scavenger Receptors pathway
Scavenging by Class A Receptors pathway
Membrane Trafficking pathway
Iron uptake and transport pathway
Transmembrane transport of small molecules pathway
Scavenging by Class A Receptors pathway
Binding and Uptake of Ligands by Scavenger Receptors pathway
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KEGG | |||||||||||||||||||||||
INOH | |||||||||||||||||||||||
PID NCI |
Validated targets of C-MYC transcriptional repression
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Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
UniGene | Mm.422193 | ||||||||||||||||||||||
RefSeq | NM_010239 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS29567 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||
MGI Symbol | |||||||||||||||||||||||
EMBL | |||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||