InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fth1

Summary

InnateDB Protein

IDBP-142807.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fth1

Protein Name

ferritin heavy chain 1

Synonyms

FHC; Fth; HFt; MFH;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025563

InnateDB Gene

IDBG-142805 (Fth1)

Protein Structure

UniProt Annotation

Function

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney. {ECO:0000269PubMed:19154717}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	8 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	35 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004322	ferroxidase activity
GO:0005515	protein binding
GO:0008199	ferric iron binding

Biological Process

GO:0006826	iron ion transport
GO:0006879	cellular iron ion homeostasis
GO:0006880	intracellular sequestering of iron ion
GO:0006955	immune response
GO:0008285	negative regulation of cell proliferation
GO:0048147	negative regulation of fibroblast proliferation
GO:0055114	oxidation-reduction process