Version 5.4
Mus musculus Gene: Mll3
Summary
InnateDB Gene IDBG-142810.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mll3
Gene Name myeloid/lymphoid or mixed-lineage leukemia 3
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000038056
Encoded Proteins
IDBP-142816
myeloid/lymphoid or mixed-lineage leukemia 3
IDBP-624889
myeloid/lymphoid or mixed-lineage leukemia 3
IDBP-624891
myeloid/lymphoid or mixed-lineage leukemia 3
IDBP-624907
myeloid/lymphoid or mixed-lineage leukemia 3
IDBP-624909
myeloid/lymphoid or mixed-lineage leukemia 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000055609:
This gene is a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family and encodes a nuclear protein with an AT hook DNA-binding domain, a DHHC-type zinc finger, six PHD-type zinc fingers, a SET domain, a post-SET domain and a RING-type zinc finger. This protein is a member of the ASC-2/NCOA6 complex (ASCOM), which possesses histone methylation activity and is involved in transcriptional coactivation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:25271798-25498783
Strand Reverse strand
Band B1
Transcripts
ENSMUST00000045291 ENSMUSP00000043874
ENSMUST00000174734 ENSMUSP00000133482
ENSMUST00000172556 ENSMUSP00000133941
ENSMUST00000172707
ENSMUST00000173673
ENSMUST00000173073 ENSMUSP00000134442
ENSMUST00000173174 ENSMUSP00000133304
ENSMUST00000172626
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0042800 histone methyltransferase activity (H3-K4 specific)
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0016571 histone methylation
GO:0035556 intracellular signal transduction
GO:0051568 histone H3-K4 methylation
Cellular Component
GO:0005634 nucleus
GO:0035097 histone methyltransferase complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000055609
View Gene Order
ENSBTAG00000024199
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00310
Lysine degradation pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00310
Lysine degradation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.332268 Mm.470986
RefSeq NM_001081383
OMIM
CCDS CCDS39033
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca