Version 5.4
Homo sapiens Gene: MLL3
Summary
InnateDB Gene IDBG-49771.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MLL3
Gene Name myeloid/lymphoid or mixed-lineage leukemia 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000055609
Encoded Proteins
IDBP-49773
myeloid/lymphoid or mixed-lineage leukemia 3
IDBP-49775
myeloid/lymphoid or mixed-lineage leukemia 3
IDBP-49777
myeloid/lymphoid or mixed-lineage leukemia 3
IDBP-387471
myeloid/lymphoid or mixed-lineage leukemia 3
IDBP-387472
myeloid/lymphoid or mixed-lineage leukemia 3
IDBP-387474
myeloid/lymphoid or mixed-lineage leukemia 3
IDBP-387479
myeloid/lymphoid or mixed-lineage leukemia 3
IDBP-597010
myeloid/lymphoid or mixed-lineage leukemia 3
IDBP-603509
myeloid/lymphoid or mixed-lineage leukemia 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family and encodes a nuclear protein with an AT hook DNA-binding domain, a DHHC-type zinc finger, six PHD-type zinc fingers, a SET domain, a post-SET domain and a RING-type zinc finger. This protein is a member of the ASC-2/NCOA6 complex (ASCOM), which possesses histone methylation activity and is involved in transcriptional coactivation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:152134922-152436005
Strand Reverse strand
Band q36.1
Transcripts
ENST00000355193 ENSP00000347325
ENST00000360104 ENSP00000353218
ENST00000262189 ENSP00000262189
ENST00000424877 ENSP00000410411
ENST00000418061 ENSP00000408001
ENST00000418673 ENSP00000403483
ENST00000452749 ENSP00000410239
ENST00000473186
ENST00000485241
ENST00000489110
ENST00000490130
ENST00000558084 ENSP00000453752
ENST00000558665 ENSP00000454058
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 32 [view]
Protein-Protein 32 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0008270 zinc ion binding
GO:0042800 histone methyltransferase activity (H3-K4 specific)
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0016571 histone methylation
GO:0032259 methylation
GO:0035556 intracellular signal transduction
GO:0051568 histone H3-K4 methylation
Cellular Component
GO:0005634 nucleus
GO:0035097 histone methyltransferase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038056
View Gene Order
ENSBTAG00000024199
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00310
Lysine degradation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.647120 Hs.649297
RefSeq NM_170606
HUGO
OMIM
CCDS CCDS5931
HPRD 06016
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca