Version 5.4
Mus musculus Gene: Arhgef5
Summary
InnateDB Gene IDBG-143130.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Arhgef5
Gene Name Rho guanine nucleotide exchange factor (GEF) 5
Synonyms 2210412D05Rik; AA717842; AW495314; Tim1
Species Mus musculus
Ensembl Gene ENSMUSG00000033542
Encoded Proteins
IDBP-143132
Rho guanine nucleotide exchange factor (GEF) 5
IDBP-789561
Rho guanine nucleotide exchange factor (GEF) 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000050327:
Rho GTPases play a fundamental role in numerous cellular processes initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein may be involved in the control of cytoskeletal organization. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:43265582-43289320
Strand Forward strand
Band B2.1
Transcripts
ENSMUST00000031750 ENSMUSP00000031750
ENSMUST00000182924 ENSMUSP00000138192
ENSMUST00000183227
ENSMUST00000183094
ENSMUST00000182190
ENSMUST00000182752
ENSMUST00000183313
ENSMUST00000182647
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
Biological Process
GO:0002408 myeloid dendritic cell chemotaxis
GO:0030036 actin cytoskeleton organization
GO:0032319 regulation of Rho GTPase activity
GO:0032321 positive regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:0035556 intracellular signal transduction
GO:0071803 positive regulation of podosome assembly
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000050327
View Gene Order
ENSBTAG00000001815
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
INOH
PID NCI
rhoa_reg_pathway
Regulation of RhoA activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_133674 XM_006506387
OMIM
CCDS CCDS51759
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca