Version 5.4
Homo sapiens Gene: ARHGEF5
Summary
InnateDB Gene IDBG-46618.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARHGEF5
Gene Name Rho guanine nucleotide exchange factor (GEF) 5
Synonyms GEF5; P60; TIM; TIM1
Species Homo sapiens
Ensembl Gene ENSG00000050327
Encoded Proteins
IDBP-46620
Rho guanine nucleotide exchange factor (GEF) 5
IDBP-479779
Rho guanine nucleotide exchange factor (GEF) 5
IDBP-483471
Rho guanine nucleotide exchange factor (GEF) 5
IDBP-477281
Rho guanine nucleotide exchange factor (GEF) 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Rho GTPases play a fundamental role in numerous cellular processes initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein may be involved in the control of cytoskeletal organization. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:144355288-144380632
Strand Forward strand
Band q35
Transcripts
ENST00000056217 ENSP00000056217
ENST00000498580 ENSP00000417979
ENST00000474817 ENSP00000418745
ENST00000471847 ENSP00000418227
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
Experimentally validated
Total 20 [view]
Protein-Protein 19 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0005525 GTP binding
Biological Process
GO:0002408 myeloid dendritic cell chemotaxis
GO:0030036 actin cytoskeleton organization
GO:0032319 regulation of Rho GTPase activity
GO:0032321 positive regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:0035556 intracellular signal transduction
GO:0071803 positive regulation of podosome assembly
Cellular Component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000033542
View Gene Order
ENSBTAG00000001815
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
INOH
PID NCI
rhoa_reg_pathway
Regulation of RhoA activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.334 Hs.624956
RefSeq NM_005435 XM_006716127 XM_006726456
HUGO
OMIM
CCDS CCDS34771
HPRD 02932
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca