Version 5.4
Mus musculus Gene: Xrcc2
Summary
InnateDB Gene IDBG-143319.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Xrcc2
Gene Name X-ray repair complementing defective repair in Chinese hamster cells 2
Synonyms 4921524O04Rik; 8030409M04Rik; RAD51; RecA
Species Mus musculus
Ensembl Gene ENSMUSG00000028933
Encoded Proteins
IDBP-143321
X-ray repair complementing defective repair in Chinese hamster cells 2
IDBP-250755
X-ray repair complementing defective repair in Chinese hamster cells 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196584:
This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene is involved in the repair of DNA double-strand breaks by homologous recombination and it functionally complements Chinese hamster irs1, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:25689812-25705825
Strand Reverse strand
Band B1
Transcripts
ENSMUST00000030773 ENSMUSP00000030773
ENSMUST00000114922 ENSMUSP00000110572
ENSMUST00000134972
ENSMUST00000131308
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000400 four-way junction DNA binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008094 DNA-dependent ATPase activity
Biological Process
GO:0000278 mitotic cell cycle
GO:0000724 double-strand break repair via homologous recombination
GO:0001701 in utero embryonic development
GO:0006200 ATP catabolic process
GO:0006259 DNA metabolic process
GO:0006281 DNA repair
GO:0006974 cellular response to DNA damage stimulus
GO:0010165 response to X-ray
GO:0010332 response to gamma radiation
GO:0042148 strand invasion
GO:0043524 negative regulation of neuron apoptotic process
GO:0050769 positive regulation of neurogenesis
GO:0051297 centrosome organization
Cellular Component
GO:0005657 replication fork
GO:0005813 centrosome
GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000196584
View Gene Order
ENSBTAG00000030897
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu03440
Homologous recombination pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa03440
Homologous recombination pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL D3Z5H2
UniProt Splice Variant
Entrez Gene 57434
UniGene Mm.143767
RefSeq NM_020570
OMIM
CCDS CCDS19135
HPRD
IMGT
MGI ID MGI:1927345
MGI Symbol Xrcc2
EMBL AC159977 CH466586
GenPept EDL03073
RNA Seq Atlas 57434

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca