InnateDB Protein
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IDBP-143321.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Xrcc2
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Protein Name
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X-ray repair complementing defective repair in Chinese hamster cells 2
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Synonyms
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4921524O04Rik; 8030409M04Rik; RAD51; RecA;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000030773
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InnateDB Gene
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IDBG-143319 (Xrcc2)
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Protein Structure
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Function |
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2- dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed at low level in somatic tissues and at high level in testis.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
8 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1927345
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InterPro |
IPR013632
DNA recombination and repair protein Rad51, C-terminal
IPR020588
DNA recombination and repair protein RecA-like, ATP-binding domain
IPR027417
P-loop containing nucleoside triphosphate hydrolase
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PFAM |
PF08423
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9CX47
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PhosphoSite |
PhosphoSite-
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TrEMBL |
D3Z5H2
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UniProt Splice Variant |
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Entrez Gene |
57434
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UniGene |
Mm.143767
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RefSeq |
NP_065595
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MGI ID |
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MGI Symbol |
Xrcc2
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OMIM |
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CCDS |
CCDS19135
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HPRD |
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IMGT |
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EMBL |
AC159977
AK014963
AK020192
BC033417
CH466586
Y17040
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GenPept |
AAH33417
BAB32023
CAA76599
EDL03073
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