Version 5.4
Mus musculus Gene: Cfc1
Summary
InnateDB Gene IDBG-143386.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cfc1
Gene Name cripto, FRL-1, cryptic family 1
Synonyms AV265756; b2b970Clo; cryptic
Species Mus musculus
Ensembl Gene ENSMUSG00000026124
Encoded Proteins
IDBP-143388
cripto, FRL-1, cryptic family 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136698:
This gene encodes a member of the epidermal growth factor (EGF)- Cripto, Frl-1, and Cryptic (CFC) family, which are involved in signalling during embryonic development. Proteins in this family share a variant EGF-like motif, a conserved cysteine-rich domain, and a C-terminal hydrophobic region. The protein encoded by this gene is necessary for patterning the left-right embryonic axis. Mutations in this gene are associated with defects in organ development, including autosomal visceral heterotaxy and congenital heart disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:34535648-34544311
Strand Forward strand
Band B
Transcripts
ENSMUST00000027298 ENSMUSP00000027298
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0070697 activin receptor binding
Biological Process
GO:0001889 liver development
GO:0001947 heart looping
GO:0003007 heart morphogenesis
GO:0007368 determination of left/right symmetry
GO:0007369 gastrulation
GO:0007492 endoderm development
GO:0009791 post-embryonic development
GO:0009952 anterior/posterior pattern specification
GO:0030509 BMP signaling pathway
GO:0038092 nodal signaling pathway
GO:0048536 spleen development
GO:0048546 digestive tract morphogenesis
GO:0048856 anatomical structure development
GO:0060070 canonical Wnt signaling pathway
GO:0060413 atrial septum morphogenesis
GO:0060460 left lung morphogenesis
GO:0060541 respiratory system development
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0031225 anchored component of membrane
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000136698
View Gene Order
Pathways
NETPATH
REACTOME
REACT_220645
Signaling by NODAL pathway
REACT_199125
Regulation of signaling by NODAL pathway
REACT_188576
Developmental Biology pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_111059
Regulation of signaling by NODAL pathway
REACT_111057
Signaling by NODAL pathway
REACT_111045
Developmental Biology pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt P97766
TrEMBL
UniProt Splice Variant
Entrez Gene 12627
UniGene Mm.2531
RefSeq NM_007685
OMIM
CCDS CCDS14869
HPRD
IMGT
MGI ID MGI:109448
MGI Symbol Cfc1
EMBL AF242430 BC100705 BC100706 BC100708 BC100711 U57720
GenPept AAC53042 AAF76323 AAI00706 AAI00707 AAI00709 AAI00712
RNA Seq Atlas 12627

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca