InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cfc1

Summary

InnateDB Protein

IDBP-143388.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cfc1

Protein Name

cripto, FRL-1, cryptic family 1

Synonyms

AV265756; b2b970Clo; cryptic;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027298

InnateDB Gene

IDBG-143386 (Cfc1)

Protein Structure

UniProt Annotation

Function

Nodal coreceptor involved in the correct establishment of the left-right axis. May play a role in mesoderm and/or neural patterning during gastrulation. {ECO:0000269PubMed:10574770, ECO:0000269PubMed:9053319}.

Subcellular Localization

Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}. Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

No expressed in adult tissues. {ECO:0000269PubMed:9053319}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0070697	activin receptor binding

Biological Process

GO:0001889	liver development
GO:0001947	heart looping
GO:0003007	heart morphogenesis
GO:0007368	determination of left/right symmetry
GO:0007369	gastrulation
GO:0007492	endoderm development
GO:0009791	post-embryonic development
GO:0009952	anterior/posterior pattern specification
GO:0030509	BMP signaling pathway
GO:0038092	nodal signaling pathway
GO:0048536	spleen development
GO:0048546	digestive tract morphogenesis
GO:0048856	anatomical structure development
GO:0060070	canonical Wnt signaling pathway
GO:0060413	atrial septum morphogenesis
GO:0060460	left lung morphogenesis
GO:0060541	respiratory system development