Version 5.4
Mus musculus Gene: Arhgef4
Summary
InnateDB Gene IDBG-143547.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Arhgef4
Gene Name Rho guanine nucleotide exchange factor (GEF) 4
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000037509
Encoded Proteins
IDBP-143549
Rho guanine nucleotide exchange factor (GEF) 4
IDBP-536525
Rho guanine nucleotide exchange factor (GEF) 4
IDBP-535462
Rho guanine nucleotide exchange factor (GEF) 4
IDBP-542692
Rho guanine nucleotide exchange factor (GEF) 4
IDBP-535039
Rho guanine nucleotide exchange factor (GEF) 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 1:34678188-34813309
Strand Forward strand
Band B
Transcripts
ENSMUST00000047664 ENSMUSP00000035980
ENSMUST00000159747 ENSMUSP00000124213
ENSMUST00000162599 ENSMUSP00000124906
ENSMUST00000159021 ENSMUSP00000124467
ENSMUST00000162760
ENSMUST00000159059
ENSMUST00000160855 ENSMUSP00000124207
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0019904 protein domain specific binding
GO:0030676 Rac guanyl-nucleotide exchange factor activity
Biological Process
GO:0030032 lamellipodium assembly
GO:0032314 regulation of Rac GTPase activity
GO:0032319 regulation of Rho GTPase activity
GO:0032855 positive regulation of Rac GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:0035556 intracellular signal transduction
GO:0043087 regulation of GTPase activity
GO:0043547 positive regulation of GTPase activity
GO:0046847 filopodium assembly
Cellular Component
GO:0005737 cytoplasm
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_223625
GPCR downstream signaling pathway
REACT_254215
Signaling by GPCR pathway
REACT_209641
NRAGE signals death through JNK pathway
REACT_206918
Signaling by Rho GTPases pathway
REACT_204413
Cell death signalling via NRAGE, NRIF and NADE pathway
REACT_204733
G alpha (12/13) signalling events pathway
REACT_210090
Rho GTPase cycle pathway
REACT_248921
Signalling by NGF pathway
REACT_188257
Signal Transduction pathway
REACT_210847
p75 NTR receptor-mediated signalling pathway
KEGG
mmu04810
Regulation of actin cytoskeleton pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.41604 Mm.436493 Mm.463312 Mm.488982
RefSeq NM_183019
OMIM
CCDS CCDS14872
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca