Version 5.4
Mus musculus Protein: Arhgef4
Summary
InnateDB Protein IDBP-536525.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Arhgef4
Protein Name Rho guanine nucleotide exchange factor (GEF) 4
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000124213
InnateDB Gene IDBG-143547 (Arhgef4)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0019904 protein domain specific binding
GO:0030676 Rac guanyl-nucleotide exchange factor activity
Biological Process
GO:0030032 lamellipodium assembly
GO:0032314 regulation of Rac GTPase activity
GO:0032319 regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:0035556 intracellular signal transduction
GO:0043087 regulation of GTPase activity
GO:0046847 filopodium assembly
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:2442507
InterPro IPR000219 Dbl homology (DH) domain
IPR001452 SH3 domain
IPR001849 Pleckstrin homology domain
IPR011511 Variant SH3 domain
PFAM PF00621
PF00018
PF14604
PF00169
PF07653
PRINTS PR00452
PIRSF
SMART SM00325
SM00326
SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q3TQN9
UniProt Splice Variant
Entrez Gene 226970
UniGene Mm.488982
RefSeq
MGI ID
MGI Symbol Arhgef4
OMIM
CCDS
HPRD
IMGT
EMBL AC107738 AC107766 AC157813 AK122448 AK163424 BC055804 BC139371 BC139397 CH466536
GenPept AAI39372 AAI39398 BAC65730 BAE37343 EDL14460

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca