Version 5.4
Mus musculus Gene: Nqo2
Summary
InnateDB Gene IDBG-143608.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nqo2
Gene Name NAD(P)H dehydrogenase, quinone 2
Synonyms NMO2; Nmor2; Ox2
Species Mus musculus
Ensembl Gene ENSMUSG00000046949
Encoded Proteins
IDBP-143610
NAD(P)H dehydrogenase, quinone 2
IDBP-143612
NAD(P)H dehydrogenase, quinone 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000124588:
NQO2 (EC 1.10.99.2) is a flavoprotein that catalyzes the 2-electron reduction of various quinones, redox dyes, and the vitamin K menadione. NQO2 predominantly uses dihydronicotinamide riboside (NRH) as the electron donor (summary by Wu et al., 1997 [PubMed 9367528]).[supplied by OMIM, Jul 2010]
This gene encodes a member of the thioredoxin family of enzymes. It is a cytosolic and ubiquitously expressed flavoprotein that catalyzes the two-electron reduction of quinone substrates and uses dihydronicotinamide riboside as a reducing coenzyme. Mutations in this gene have been associated with neurodegenerative diseases and several cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:33964659-33988465
Strand Forward strand
Band A3.3
Transcripts
ENSMUST00000021843 ENSMUSP00000021843
ENSMUST00000058978 ENSMUSP00000053809
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001512 dihydronicotinamide riboside quinone reductase activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
Biological Process
GO:0007613 memory
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000124588
View Gene Order
ENSBTAG00000000786
Not yet available
Cross-References
SwissProt Q9JI75
TrEMBL
UniProt Splice Variant
Entrez Gene 18105
UniGene Mm.264036
RefSeq NM_020282 XM_006516574 NM_001163239 NM_001163241 NM_001163242
OMIM
CCDS CCDS26442
HPRD
IMGT
MGI ID MGI:104513
MGI Symbol Nqo2
EMBL AF252260 AF254076 AF254077 AF254078 AF254079 AF254080 AF254081 AK010842 BC027629
GenPept AAF97785 AAF97789 AAH27629 BAB27217
RNA Seq Atlas 18105

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca