Version 5.4
Mus musculus Protein: Nqo2
Summary
InnateDB Protein IDBP-143612.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nqo2
Protein Name NAD(P)H dehydrogenase, quinone 2
Synonyms NMO2; Nmor2; Ox2;
Species Mus musculus
Ensembl Protein ENSMUSP00000053809
InnateDB Gene IDBG-143608 (Nqo2)
Protein Structure
UniProt Annotation
Function The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001512 dihydronicotinamide riboside quinone reductase activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
Biological Process
GO:0007613 memory
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:104513
InterPro IPR003680 Flavodoxin-like fold
IPR005025 NADPH-dependent FMN reductase-like
IPR029039 Flavoprotein-like
PFAM PF02525
PF03358
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9JI75
PhosphoSite PhosphoSite-Q9JI75
TrEMBL
UniProt Splice Variant
Entrez Gene 18105
UniGene Mm.264036
RefSeq NP_001156714
MGI ID
MGI Symbol Nqo2
OMIM
CCDS CCDS26442
HPRD
IMGT
EMBL AF252260 AF254076 AF254077 AF254078 AF254079 AF254080 AF254081 AK010842 BC027629
GenPept AAF97785 AAF97789 AAH27629 BAB27217

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca