Version 5.4
Mus musculus Gene: Ripk1
Summary
InnateDB Gene IDBG-143710.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ripk1
Gene Name receptor (TNFRSF)-interacting serine-threonine kinase 1
Synonyms D330015H01Rik; Rinp; RIP; Rip1
Species Mus musculus
Ensembl Gene ENSMUSG00000021408
Encoded Proteins
IDBP-143712
receptor (TNFRSF)-interacting serine-threonine kinase 1
IDBP-620079
receptor (TNFRSF)-interacting serine-threonine kinase 1
IDBP-620080
receptor (TNFRSF)-interacting serine-threonine kinase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 16543241
[Homo sapiens] RIPK1 ubiquitination on Lys377 is required for tumour necrosis factor (TNF-alpha) induced NF-kappaB activation.
PMID 16825191
[Homo sapiens] RIPK1 is a death domain kinase that is one of the critical components involved in mediating DNA damage-induced, p53-independent cell death.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000137275:
Gene Information
Type Protein coding
Genomic Location Chromosome 13:34002363-34035170
Strand Forward strand
Band A3.3
Transcripts
ENSMUST00000021844 ENSMUSP00000021844
ENSMUST00000163418
ENSMUST00000167374 ENSMUSP00000129831
ENSMUST00000171137 ENSMUSP00000128511
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 61 experimentally validated interaction(s) in this database.
They are also associated with 111 interaction(s) predicted by orthology.
Experimentally validated
Total 61 [view]
Protein-Protein 61 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 111 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005123 death receptor binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0031625 ubiquitin protein ligase binding
GO:0032403 protein complex binding
GO:0042802 identical protein binding
GO:0070513 death domain binding
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0010942 positive regulation of cell death
GO:0016032 viral process
GO:0032757 positive regulation of interleukin-8 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0034612 response to tumor necrosis factor
GO:0036289 peptidyl-serine autophosphorylation
GO:0042327 positive regulation of phosphorylation
GO:0043065 positive regulation of apoptotic process
GO:0043068 positive regulation of programmed cell death
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043410 positive regulation of MAPK cascade
GO:0044257 cellular protein catabolic process
GO:0045651 positive regulation of macrophage differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046330 positive regulation of JNK cascade
GO:0046777 protein autophosphorylation
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051260 protein homooligomerization
GO:0051291 protein heterooligomerization
GO:0051347 positive regulation of transferase activity
GO:0060545 positive regulation of necroptotic process
GO:0070231 T cell apoptotic process
GO:0070266 necroptotic process
GO:0070926 regulation of ATP:ADP antiporter activity
GO:0071356 cellular response to tumor necrosis factor
GO:0071363 cellular response to growth factor stimulus
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097343 ripoptosome assembly
GO:0097527 necroptotic signaling pathway
GO:1901026 ripoptosome assembly involved in necroptotic process
GO:1990000 amyloid fibril formation
GO:2000377 regulation of reactive oxygen species metabolic process
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0005739 mitochondrion
GO:0031264 death-inducing signaling complex
GO:0043234 protein complex
GO:0043235 receptor complex
GO:0045121 membrane raft
GO:0097342 ripoptosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000137275
View Gene Order
ENSBTAG00000006378
Not yet available
Pathways
NETPATH
REACTOME
REACT_263316
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_239142
Innate Immune System pathway
REACT_196640
Stimuli-sensing channels pathway
REACT_258521
Apoptosis pathway
REACT_243608
Dimerization of procaspase-8 pathway
REACT_215863
ZBP1(DAI) mediated induction of type I IFNs pathway
REACT_230745
Immune System pathway
REACT_256171
TNF signaling pathway
REACT_241657
Caspase-8 activation by cleavage pathway
REACT_257735
Death Receptor Signalling pathway
REACT_215122
Regulation by c-FLIP pathway
REACT_262350
Ion channel transport pathway
REACT_251547
Toll-Like Receptors Cascades pathway
REACT_218897
Cytosolic sensors of pathogen-associated DNA pathway
REACT_253400
Transmembrane transport of small molecules pathway
REACT_196636
TRIF-mediated programmed cell death pathway
REACT_205717
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 pathway
REACT_222971
RIP-mediated NFkB activation via ZBP1 pathway
REACT_259850
Extrinsic Pathway for Apoptosis pathway
REACT_262462
Activated TLR4 signalling pathway
REACT_226192
IKK complex recruitment mediated by RIP1 pathway
REACT_241786
MyD88-independent cascade pathway
REACT_219118
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
REACT_238546
TRIF-mediated TLR3/TLR4 signaling pathway
REACT_227861
TRP channels pathway
REACT_246719
Toll Like Receptor 4 (TLR4) Cascade pathway
KEGG
mmu04620
Toll-like receptor signaling pathway pathway
mmu04210
Apoptosis pathway
mmu04622
RIG-I-like receptor signaling pathway pathway
mmu04623
Cytosolic DNA-sensing pathway pathway
mmu05160
Hepatitis C pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
INOH website
TNFR1 signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
NetPath_9
TNFalpha pathway
NetPath_26
TWEAK pathway
REACTOME
REACT_118563
RIP-mediated NFkB activation via ZBP1 pathway
REACT_118764
ZBP1(DAI) mediated induction of type I IFNs pathway
REACT_25039
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 pathway
REACT_25359
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
REACT_25374
IKK complex recruitment mediated by RIP1 pathway
REACT_150361
TRIF-mediated programmed cell death pathway
REACT_6809
MyD88-independent cascade pathway
REACT_6783
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_6894
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_160189
Stimuli-sensing channels pathway
REACT_832
Dimerization of procaspase-8 pathway
REACT_1503
Caspase-8 activation by cleavage pathway
REACT_1432
TNF signaling pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_1059
Extrinsic Pathway for Apoptosis pathway
REACT_6802
Innate Immune System pathway
REACT_6966
Toll-Like Receptors Cascades pathway
REACT_578
Apoptosis pathway
REACT_6900
Immune System pathway
REACT_25300
Ion channel transport pathway
REACT_6890
Activated TLR4 signalling pathway
REACT_25281
TRIF-mediated TLR3/TLR4 signaling pathway
REACT_118823
Cytosolic sensors of pathogen-associated DNA pathway
REACT_169333
TRP channels pathway
REACT_164011
Regulation by c-FLIP pathway
REACT_1619
Death Receptor Signalling pathway
KEGG
hsa04210
Apoptosis pathway
hsa04620
Toll-like receptor signaling pathway pathway
hsa04622
RIG-I-like receptor signaling pathway pathway
hsa04623
Cytosolic DNA-sensing pathway pathway
hsa05160
Hepatitis C pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
INOH website
TNFR1 signaling pathway pathway
PID NCI
ceramide_pathway
Ceramide signaling pathway
caspase_pathway
Caspase Cascade in Apoptosis
tnfpathway
TNF receptor signaling pathway
trail_pathway
TRAIL signaling pathway
p38alphabetapathway
Regulation of p38-alpha and p38-beta
hivnefpathway
HIV-1 Nef: Negative effector of Fas and TNF-alpha
faspathway
FAS (CD95) signaling pathway
Cross-References
SwissProt Q60855
TrEMBL
UniProt Splice Variant
Entrez Gene 19766
UniGene Mm.374799
RefSeq NM_009068 XM_006516607 XM_006516608 XM_006516609
OMIM
CCDS CCDS26443
HPRD
IMGT
MGI ID MGI:108212
MGI Symbol Ripk1
EMBL AK030959 AK156803 BC050905 BC054542 BC058162 U25995
GenPept AAB60487 AAH50905 AAH54542 AAH58162 BAC27194 BAE33860
RNA Seq Atlas 19766

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca