Version 5.4
Mus musculus Gene: Frem2
Summary
InnateDB Gene IDBG-143716.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Frem2
Gene Name Fras1 related extracellular matrix protein 2
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000037016
Encoded Proteins
IDBP-143718
Fras1 related extracellular matrix protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000150893:
This gene encodes a membrane protein that belongs to the FRAS1 family. This extracellular matrix protein is thought to be required for maintaining the integrity of the skin epithelium and the differentiated state of renal epithelia. The protein localizes to the basement membrane, forming a ternary complex that plays a role in epidermal-dermal interactions during morphogenetic processes. Mutations in this gene are associated with Fraser syndrome. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:53513939-53657355
Strand Reverse strand
Band C
Transcripts
ENSMUST00000091137 ENSMUSP00000088670
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
Biological Process
GO:0002009 morphogenesis of an epithelium
GO:0007154 cell communication
GO:0007156 homophilic cell adhesion
GO:0048839 inner ear development
Cellular Component
GO:0005604 basement membrane
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000150893
View Gene Order
ENSBTAG00000017032
Not yet available
Cross-References
SwissProt Q6NVD0
TrEMBL
UniProt Splice Variant
Entrez Gene 242022
UniGene Mm.38378 Mm.406324
RefSeq NM_172862 XM_006501462
OMIM
CCDS CCDS17348
HPRD
IMGT
MGI ID MGI:2444465
MGI Symbol Frem2
EMBL AB160988 AJ833643 AK031494 AK082256 BC046388 BC068185
GenPept AAH46388 AAH68185 BAC27425 BAC38448 BAD89016 CAH55760
RNA Seq Atlas 242022

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca